Simon Brack,Frédéric Mourlane,Isabella Toller,Richard Woods,Julian Bertschinger,Dragan Grabulovski,Babette Schade,Kristina Klupsch,Helen Hachemi
申请号：
US14385729
公开号：
US20150047065A1
申请日:
2013.03.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumor cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumor cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumor cells. The present invention further relates to a nucleic acid molecule encoding the binding molecule of the invention, a vector comprising said nucleic acid molecule as well as a host cell or a non-human host transformed with said vector. The invention further relates to a method of producing a binding molecule of the invention as well as to pharmaceutical and diagnostic composition. Moreover, the present invention also relates to the binding molecule, the nucleic acid molecule, the vector or the host cell of the invention for use in the treatment of tumors.
