The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain -alkylcarbonyl-amino acid ester and -alkylcarbonyl-amino lactone compounds as described herein； compositions and articles comprising such compounds； and methods of treatment, for example, methods of alleviating the discomforts of irritation, itch, and pain in the skin and in the linings of the oral cavity and upper respiratory tract, for example, in methods of treatment of cough and/or asthma.
