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Diagnosis and treatment of gastric-type cancers with siRNA, modified antibodies, or immunotherapy approaches
专利权人:
JOHANNES GUTENBERG - UNIVERSITAT MAINZ
发明人:
SAHIN, UGUR,TURECI, OZLEM,KOSLOWSKI, MICHAEL
申请号:
NZ59447910
公开号:
NZ594479A
申请日:
2010.02.18
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
Patent No. 594479 Disclosed is the use of an inhibitor of expression and/or activity of a tumor antigen for the preparation of a pharmaceutical composition for treating or preventing a tumor disease, wherein said tumor antigen comprises an amino acid sequence encoded by a nucleic acid which comprises the nucleic acid sequence according to SEQ ID NO: 1 of the sequence listing or a variant of said nucleic acid sequence, wherein (i) the inhibitor of expression of a tumor antigen is an inhibitory nucleic acid selectively hybridizing to the nucleic acid which comprises the nucleic acid sequence according to SEQ ID NO: I of the sequence listing or a variant of said nucleic acid sequence, or (ii) the inhibitor of activity of a tumor antigen is an antibody specifically binding to said tumor antigen, wherein said variant is a functional variant and said tumor disease is a cancer of the stomach, a gastric cancer, a gastric carcinoma, an adenocarcinoma of the stomach or a metastasis thereof.
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