PROBLEM TO BE SOLVED: To provide anti-Notch ligand Delta-like 4 (DLL4) antibodies associated with angiogenesis, and methods of using the anti-DLL4 antibodies as therapeutic agents in diseases or disorders associated with DLL4.SOLUTION: The invention provides: anti-DLL4 antibodies or antigen-binding fragments having specific sequences； anti-DLL4 antibodies or antigen-binding fragments thereof that specifically bind to human DLL4； and anti-DLL4 antibodies having a complementary determining region (CDR) and comprising at least one of heavy chain CDRH1, heavy chain CDRH2, heavy chain CDRH3, light chain CDRL1, light chain CDRL2 and light chain CDRL3.SELECTED DRAWING: None【課題】血管新生に関連する抗Ｎｏｔｃｈリガンドのデルタ様４（DLL4）抗体及びDLL4に関連した疾患又は障害における治療薬として抗DLL4抗体の使用法の提供。【解決手段】特定の配列を有するanti-DLL4抗体または抗原結合性破片。抗DLL4抗体又はヒトDLL4に特異的に結合するその抗原結合フラグメント。相補決定領域(CDR)を有しており、重鎖CDRH1、重鎖CDRH2、重鎖CDRH3、軽鎖CDRL1、軽鎖CDRL2又は軽鎖CDRL3の少なくとも1つを含む抗DLL4抗体。【選択図】なし
