Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof

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专利权人:

Allergan; Inc.

发明人:

Burk, Robert M.,Im, Wha Bin

申请号：

AU2010328555

公开号：

AU2010328555B2

申请日:

2010.11.05

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders.

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