The present invention relates to anti-CDH3 antibody, can use labelled with radioisotope. Moreover, the method provided by the present invention and pharmaceutical composition, it includes a kind of anti-CDH3 antibody as active constituent. Since CDH3 is strongly expressed in pancreas, lung, colon, prostate, mammary gland, stomach or liver cancer cells, the present invention can be used for the treatment of cancer of pancreas, lung cancer, colon cancer, prostate cancer, breast cancer, gastric cancer and liver cancer.
