LI, Yun-Long,BURNS, David M.,FENG, Hao,XUE, Chu-Biao,WANG, Anlai,PAN, Jun
申请号：
ES14702167
公开号：
ES2649156T3
申请日:
2014.01.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: Cy is C3-7 unsubstituted or substituted cycloalkyl or 4-10 membered substituted or unsubstituted heterocycloalkyl, wherein the atoms of the heterocycloalkyl ring consist of carbon atoms and 1, 2 or 3 heteroatoms selected from O, N or S, in which the C3-7 substituted cycloalkyl or substituted heterocycloalkyl of 4-10 forming members of Cy is substituted with 1, 2, 3, 4 or 5 substituents each independently selected from halogen, RCy1, C1-6 haloalkyl, CN, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1, OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, C (>； = NRe1) NRc1Rd1, NRc1C (>； = NRe1) NRc1Rd1, S (O) Rb1 S (O) NRc1Rd1, S (O) 2Rb1, NRc1S (O) 2Rb1 and S (O) 2NRc1Rd1, in which each RCy1 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6- 10 aryl, 5-10 membered heteroaryl, C3-7 cycloalkyl and heterocyclic 4-7-member loalkyl, each of which is independently unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, RCy2, C1-6 haloalkyl, CN, ORa1, SRa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1, OC (O) Rb1, OC (O) NRc1Rd1, NRc1Rd1, NRc1C (O) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, C (>； = NRe1) NRc1Rd1 , NRc1C (>； = NRe1) NRc1Rd1, S (O) Rb1, S (O) NRc1Rd1, S (O) 2Rb1, NRc1S (O) 2Rb1 and S (O) 2NRc1Rd1, and in which each RCy2 is independently C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, C3-7 cycloalkyl and 4-7 membered heterocycloalkyl, each of which is independently unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, CN, ORa1, C (O) Rb1, C (O) NRc1Rd1, C (O) ORa1, OC (O) Rb1, OC (O) NRc1Ra1, NRc1Ra1, NRc1C (O) Rb1, NRc1C (O) NRc1Rd1, NRc1C (O) ORa1, S (O) Rb1, S (O) NRc1Rd1, S (O) 2Rb1 and S (O) 2NRc1Rd1； A 1 is N or CR1； R1 is H, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, ORa2
