Provided is a medicament comprising cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide for the long term treatment of 4 weeks or more of a disease or condition which is one indicated for NSAID use in a human patient, wherein cobiprostone is administered at least 36 mcg per day, to the patient who receives a NSAID. By administering cobiprostone or its pharmaceutically acceptable salt, ester, ether or amide in combination with a NSAID, the patient can receive the NSAID for longer time period.
