A method of producing, at a high conversion rate and with good reproducibility, a 3?[(S)?7?bromo?2?(2?oxo?propylamino)?5?pyridine?2?yl?3H?1,4?benzodiazepine?3?yl]methyl propionate through the oxidization of a 3?[(S)?7?bromo?2?(2?hydroxy?propylamino)?5?pyridine?2?yl?3H?benzo[e][1,4]diazepine?3?yl]methyl propionate by means of an oxidation catalyst is provided by regulating the ammonium ion content of the 3?[(S)?7?bromo?2?(2?hydroxy?propylamino)?5?pyridine?2?yl?3H?benzo[e][1,4]diazepine?3?yl]methyl propionate.