< Topic >Useful chemical compound is offered as a active ingredient of the medicine constituent for remedy of disease where FAAH participates.SolutionsThese inventors, ardency possessing the FAAH inhibition activity where the piperazine 1 carboxylate chemical compound which the result, the benzimid azole 2 yl-carbonyl and the benzo furan 2 yl-carbonyl etc which were examined join to piperazine 4 rank is superior, furthermore verified that it possesses the anesthetic operation the effective bladder capacity increase operation, sleep fault improvement operation, anti- diuresis operation, and bladder painfully and so on lower part urine path painfully for concerning the chemical compound which possesses FAAH inhibition activity, completed this invention. The karubameto chemical compound of this invention has the FAAH inhibition activity which is superior, can use the disease and the especially nighttime pollakiuria where FAAH participates, the between quality Characteristic cystitis, painfulness bladder syndrome or the chronic non-bacterial prostate flame/the chronic Pelvis painfully prevention of syndrome and/or as the remedy medicine.< Choice figure >It is not【課題】FAAHが関与する疾患の治療用医薬組成物の有効成分として有用な化合物を提供する。【解決手段】本発明者らは、FAAH阻害活性を有する化合物について鋭意検討した結果、ベンゾイミダゾール-2-イルカルボニル、ベンゾフラン-2-イルカルボニル等がピペラジン4位に結合するピペラジン-1-カルボキシレート化合物が優れたFAAH阻害活性を有すること、更に有効膀胱容量増大作用、睡眠障害改善作用、抗利尿作用、及び膀胱痛等の下部尿路痛に対する鎮痛作用を有することを確認し、本発明を完成した。本発明のカルバメート化合物は優れたFAAH阻害活性を有し、FAAHが関与する疾患、特に夜間頻尿、間質性膀胱炎、有痛性膀胱症候群又は慢性非細菌性前立腺炎/慢性骨盤痛症候群の予防及び/又は治療剤として使用しうる。【選択図】なし
