The invention relates to methods of evaluating MS severity based on analysis of single nucleotide polymorphisms (SNPs) and to products and kits for use in such methods. The methods include a method of assessing a multiple sclerosis disease severity phenotype in a human subject having multiple sclerosis, by determining the genotype of the subject at one or more positions of single nucleotide polymorphism (SNP) selected from: rs2107538, rsl 137933, rsl318, rs2069763, rs423904, rs876493, rsl0243024, rsl0259085, rslO42173, rsl0492503, rsl0492972, rsl2047808, rsl2202350, rsl2861247, rsl3353224, rsl350666, rsl555322, rsl611115, rsl7641078, rsl805009, rs2028455, rs2032893, rs2049306, rs2066713, rs2074897, rs2076530, rs2187668, rs2213584, rs2227139, rs2234978, rs2239802, rs2395182, rs260461, rs28386840, rs3087456, rs3135388, rs3741981, rs375645O, rs3781202, rs3787283, rs38O8585, rs4128767, rs4404254, rs4473631, rs4680534, rs6077690, rs6457594, rs6570426, rs659366, rs6917747, rs7208257, rs7528684, rs7577925, rs762550, rs7956189, rs7995215, rs8049651, rs8702, rs9808753 and rs987107, and/or a SNP in linkage disequilibrium with any one of said SNPs.La présente invention concerne des procédés dévaluation de la gravité de la sclérose en plaques basée sur lanalyse de polymorphismes de nucléotide unique (SNP) et des produits et des trousses pour utilisation dans de tels procédés. Les procédés comprennent un procédé dévaluation dun phénotype de gravité de la maladie de sclérose en plaques chez un sujet humain ayant la sclérose en plaques, par détermination du génotype du sujet à une ou plusieurs positions de polymorphisme de nucléotide unique (SNP) choisies parmi : rs2107538, rs1137933, rs1318, rs2069763, rs423904, rs876493, rs10243024, rs10259085, rs1042173, rs10492503, rs10492972, rs12047808, rs12202350, rs12861247, rs13353224, rs1350666, rs1555322, rs1611115, rs17641078, rs1805009, rs2028455, rs2032893, rs2049306, rs2066713, rs2074897, rs2076530, rs2187668, rs2213584, rs2227139,
