The invention provides compounds of Formula 1: or a stereoisomer, pharmaceutically acceptable salt, or mixture thereof; and methods of making and using such compounds. The invention includes pharmaceutical compositions containing such compounds, and the use of such compounds in methods of treating conditions, diseases, or disorders.本發明提供式1化合物: 或其立體異構物、醫藥上可接受之鹽、或混合物;及製造及使用此等化合物之方法。本發明包括含有此等化合物之醫藥組成物,及此等化合物在治療病況、疾病或病症之方法中之用途。