Provide method, it uses, and composition, it is used to handle acute myeloid leukemia, and treatment ground includes -4- [4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl of 6 ethyl -3-({, 3 methoxyl groups } amino) -5 (tetrahydro -2H- pyrans -4-ylamino) pyrazine-2-carboxamides or a salt, and 4 amino -1- β-D- fugusted nitrosoureas -1, the effective combination of 3,5- triazins -2 (1H)-mono- or a kind of salt.