SNYDER LINDA,POWERS GORDON,PECHENICK DOV,ROTHSTEIN JAY,MOLLOY MICHAEL
申请号：
CL2019002195
公开号：
CL2019002195A1
申请日:
2019.08.05
申请国别(地区):
CL
年份:
2020
代理人:
摘要：
26lt p 26gt (57) Abstroct The iuvcntiou providcs autagonistic and agonistic nnli -humru1 VISTA llltiboctie aud autibody fragmcnts Thcsc ant - 26lt br 2F 26gtagorlist ullibodies and autibody f ragmcuts may be used to inh ibit or block VISTA 26amp 2339 s suppressive efTects on T cell iuununity aud 3D lhe reby promote T ceU inmtunity These agor 26amp uacute st auJiboctics and antibody fragrnerns may be used to potentiate or euhancc or mimic V ST A 26amp 2339 s suppress ivc effects on T ccll immunity ancl therehy wppress T cell immunity Thcso antagonist antibodies and antibody O frugmcuts are especially useful in the treannent of canc 26amp lt r and infcclious conditions These agonist antibodies and antibody fragments 26amp gt rife cspecially 26amp iexcl 26amp iexcl Scrcening a says for identit) 26amp 2339 iug these agonists a re also providcd 26lt 2Fp 26gt<；p>；(57) Abstroct: The iuvcntiou providcs autagonistic and agonistic nnli -humru1 VISTA !llltiboctie~ aud autibody fragmcnts. Thcsc ant -<；br />；~ agorlist :ullibodies and autibody f.ragmcuts may be used to inh.ibit or block VISTA'；s suppressive efTects on T cell iuununity aud = lhe.reby promote T ceU inmtunity. These agorú；st auJiboctics and antibody fragrnerns may be used to potentiate or euhancc or mimic<；br />；~ V!ST A'；s suppress ivc effects on T ccll immunity ancl therehy wppress T cell immunity. Thcso antagonist antibodies and antibody O frugmcuts are especially useful in the treannent of canc<；:r and infcclious conditions. These agonist antibodies and antibody fragments >； rife cspecially useful iu tbc treatment of autoimm!lllity, allergy, inllammatory couditions. GVHD, scpsis and transp1ant recipieots.<；br />；；.¡；¡；. Scrcening a~says for identit)'；iug these agonists a.re also providcd.<；/p>；
