Oregon Health & Science University;University of Maryland, Baltimore;The United States Government as Represented by the Department of Veterans Affairs
发明人:
Arthur A. Vandenbark,Roberto Meza-Romero,Richard Alexander,Elena Klyushnenkova
申请号：
US15400587
公开号：
US20170196957A1
申请日:
2017.01.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the first domain is an MHC class II β1 domain and the second domain is an MHC class II α1 domain, wherein the amino terminus of the α1 domain is covalently linked to the carboxy terminus of the β1 domain, and a prostate specific antigen peptide covalently linked to the first domain. The methods include administering a disclosed MHC molecule to a subject with prostate cancer.
