The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides fused heterocyclic derivatives represented by the following general formula (I), pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A is 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl； R A is halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.； ring B is aryl or heteroaryl； R B is halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl, etc.； E 1 and E 2 are oxygen atom, etc.； U is single bond or alkylene； X is a group represented by Y, -O-(alkylene)-Y or -O-Z (in which Y is Z or amino substituted by Z, etc.； Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.
