DEGRADATION DE LA PROTEINE A MOTIF TRIPARTIE 24 (TRIM24) PAR CONJUGAISON D'INHIBITEURS DE TRIM24 AVEC UN LIGAND DE LA LIGASE E3 ET PROCEDES D'UTILISATION
The present application provides bifunctional compounds of Formula Ia or Ib: (Ia), or Targeting Ligand (Ib), Targeting Ligand or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which act as protein degradation inducing moieties for tripartite motif-containing 24 (TRIM24). The present application also relates to methods for the targeted degradation of TRIM24 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to TRIM24 which can be utilized in the treatment of disorders modulated by TRIM24.
