Double acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonists / blockers (arb) and neutral endopeptidase (nep) inhibitors
Al-Fayoumi, Suliman,Hu, Jiahui,Kumaraperumal, Natrajan,ROYCE, Alan Edward,RUEGGER, Colleen,Zannou, Erika Aina
申请号：
DK10173506
公开号：
DK2295035T3
申请日:
2008.11.04
申请国别(地区):
DK
年份:
2016
代理人:
摘要：
Solid oral dosage forms, especially tablets, of a pharmaceutical composition comprising a supramolecular complex can be formed from a direct compression process or a compaction process such as roller compaction. Such solid oral dosage forms feature an immediate release profile that allows for fast release of the therapeutic agent. A particularly useful supramolecular complex is trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3'-methyl-2'-(pentanoyl{2"-(tetrazol-5-ylate)biphenyl-4'-ylmethyl}amino)butyrate]hemipentahydrate.
