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РЕТ-АГЕНТЫ ДЛЯ ВИЗУАЛИЗАЦИИ АПОПТОЗА
专利权人:
ДжиИ Хелткер Лимитед (GB)
发明人:
ХИКОК Дункан (GB),АРБО Бенте Элизабет (NO),МАКРОББИ Грэм Уолтер (GB),ИНДРЕВОЛЛ Бард (NO),БХАЛЛА Раджив (AU)
申请号:
RU2013123909/04
公开号:
RU2013123909A
申请日:
2011.12.01
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The imaging agent comprising the compound of formula I: wherein represents lantibiotichesky LBP peptide of formula II: Xaa is Arg or Lys Cys-Thr, Ser-Cys-Cysi Thrkovalentno connected via thioether bonds Ser-Lyskovalentno lizinoalanin connected through communication HO-Asp represents β-gidroksiasparaginovuyu acid Z- (L) - attached to Cysi also possible to Xaa at LBP, wherein a Zpredstavlyaet liboF, liboF coordinated to the metal of the metal complex Zprisoedinen to the C-terminus of LBP and represents OH or OM where Vpredstavlyaet with oboj biocompatible cation and L is a synthetic linker group of formula - (A) -, wherein each A independently represents -CR-, -CR = CR-, -S≡S-, -CRCO-, -COCR-, -NRCO-, -CONR- , -CR = NO-, -NR (C = O) NR-, -NR (C = S) NR-, -SONR-, -NRSO-, -CROCR-, -CRSCR-, -CRNRCR-, C-tsiklogeteroalkilenovuyu group Stsikloalkilenovuyu group, -Ar-, -NR-Ar-, -O-Ar-, -Ar- (CO) -, amino acid, sugar or a monodisperse polyethylene glycol (PEG) structural unit wherein each Ar independently represents a group or Carilenovuyu Cgeteroarilenovuyu group each R is independently selected from H, Ci ^ alkyl, alkenyl, Calkinila, Calkoksialkila or Cgidroksialkila m prev nent an integer from 1 to 20 n represents an integer of 0 or 1.2. Imaging agent according to claim 1, wherein only Zprisoedinen Cysv LBP.3. Imaging agent according to claim 1 or 2 wherein Xaa represents Arg.4. Imaging agent according to claim 1, wherein Z- (L) - comprises a group of formula X, wherein x is an integer from 0 to 5 Xvybran from -Ar-, -Ar-NR-, -Ar-O-, -Ar - (CO) - or -Si (R) - wherein a, Ar and R are as defined for the group L in claim 1 and each independently represents Calkil.5. Imaging agent of claim 4, wherein, on the phenyl ring or Arsoderzhit geterotsik1. Визуализирующий агент, содержащий соединение формулы I:где LBP представляет собой лантибиотический пептид формулы II:Хаа представляет собой Arg или LysCysa-Thra, Serb-Cysb и Cysc-Thrc ковалентно соединены посредством простых тиоэфи
来源网站:
中国工程科技知识中心
来源网址:
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