Surgical devices and methods are described. The surgical devices can generally include a housing having one or more actuators such as a closure actuator (106). An elongate shaft (104) can extend distally from the housing and an end effector (130) can be selectively coupled to a distal end of the shaft. The surgical device can include various features that prevent a user from actuating the device when the end effector is not properly coupled to the shaft. More specifically, the housing can include a locking member (112) that can be pivoted or otherwise move relative the housing to cause various internal features of the housing to move to a ready-to-load position. With the locking member and actuator so positioned, an end effector can be loaded onto the shaft and the locking member can be moved from the ready-to-load position to the ready-to-actuate position, thus allowing the closure actuator to be in a ready-to-actuate position.