California Institute of Technology;The Regents of the University of California
发明人:
Brittany D. Needham,Sarkis K. Mazmanian,Gil Sharon,Masanori Funabashi,Michael A. Fischbach,Elaine Y. Hsiao,Paul H. Patterson
申请号：
US16485403
公开号：
US20190374588A1
申请日:
2018.02.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Some embodiments relate to genetically engineered bacterial strains for modulation of levels of the bacterial metabolite 4-ethylphenol (4EP) and its sulfated form, 4-ethylphenyl sulfate (4EPS). In some embodiments, the bacteria reduce or inhibit production of 4EP or 4EPS in the gut of a subject. The bacteria can ameliorate, delay the onset or reduce the likelihood of one or more symptoms associated with anxiety and/or autism spectrum disorder (ASD) in the subject.
