The invention provides compositions including a fusion polypeptide and methods for making a fusion polypeptide that includes a COF1/CRBN-binding polypeptide, COF2/CRBN-binding polypeptide, or COF3/CRBN-binding polypeptide and a heterologous polypeptide of interest.本發明提供包括融合多肽之組合物及用於製備融合多肽之方法,該融合多肽包括COF1/CRBN結合多肽、COF2/CRBN結合多肽或COF3/CRBN結合多肽及相關異源多肽。