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הרכב שחרור מותאם של orlistat ו-acarbose לטיפול בהשמנת יתר והפרעות מטאבוליות קשורות
专利权人:
Ulf HOLMBACK;Anders FORSLUND;EMPROS PHARMA AB;Goran ALDERBORN;Jan Stefan Persson GRUDEN;Hans LENNERNAS
发明人:
Goran ALDERBORN,Anders FORSLUND,Ulf HOLMBACK,Hans LENNERNAS,Jan Stefan Persson GRUDEN
申请号:
IL25286517
公开号:
IL252865D0
申请日:
2017.06.13
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.
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