[Document Name] ABSTRACTAn object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the folio wing formula (I) (wherein RI represents a halogen atom； R2 represents a C1.12 alkyl group, a C2-I2 alkenyl group, a C2.12 alkynyl group, a C3-8 cycloalkyl g roup, an aryl group, an ar-C1_6 alkyl group or a heterocyclic group, each opti onally having at least one substituent； R3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent； and R4 and R5 e ach independently represent a hydrogen atom； and R2 and R4 may form a cyclic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.
