Pharmaceutical compositions containing paclitaxel orotate

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专利权人:

Rashida A. Karmali

发明人:

Rashida A. Karmali

申请号：

US13066793

公开号：

US08415388B2

申请日:

2011.04.25

申请国别(地区):

US

年份:

2013

代理人:

摘要：

This invention is related to orotic acid compounds of taxane cytotoxic agents and in particular to the conversion of the taxanes to their orotate esters. More particularly the pharmaceutical compositions of paclitaxel orotate and docetaxel orotate provide a strategy to minimize body weight loss during primary chemotherapy and improve patient outcomes and quality of life.

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