The present invention relates to novel lipopeptide compounds, pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The compounds of the invention are particularly useful against a variety of bacteria, including resistant strains. The compounds are useful as antibacterial agents againstClostridium difficile.本發明係關於新穎脂肽化合物、該等化合物之醫藥組合物,以及使用該等化合物作為抗菌化合物的方法。本發明化合物特別適用於對抗各種細菌,包括抗藥性菌株。該等化合物適用作對抗難養芽胞梭菌(Clostridium difficile)之抗菌劑。