Иващенко Александр Васильевич (RU),Иващенко Андрей Александрович (RU),Бычко Вадим Васильевич (US),Хват Александр Викторович (US),Савчук Николай Филиппович (RU),Роговой Борис (US)
申请号：
RU2015104886
公开号：
RU2015104886A
申请日:
2015.02.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. Inhibitors of replication of hepatitis B virus, which are arylamides bis-9-oxo-9H-fluorene-2,7-disulfonic acid of the general formula 1, their pharmaceutically acceptable salts and / or gidratygde Arpredstavlyayut Ari is phenyl optionally substituted with one, two or three same or different substituents selected from C-alkyl, methoxy, halogen, carboxyl and carbamoyl optionally substituted by identical or different substituents, where the substituents are selected from C-alkyl, diC-SalkilaminoS-alkyl, S-alkyl or-SalkilaminoS replaced where Titel together with the nitrogen atom to which they are attached may form a 6-membered heterocyclyl containing further heteroatom selected from nitrogen and optionally substituted C Salkilom.2. Inhibitor according to Claim. 1, representing a bis-aryl amide 9-oxo-9H-fluorene-2,7-disulfonic acid selected from a number of compounds of Formula 1.1-1.123. A pharmaceutical composition in the form of tablets, capsules, or injections, placed in pharmaceutically acceptable packing intended for treatment of hepatitis B containing the replication of hepatitis C virus inhibitor in the general formula of claim 1. 1, its pharmaceutically acceptable salt and / or hydrate thereof in a therapeutically effective kolichestve.4. A process for preparing a pharmaceutical composition by mixing with the inert filler and / or diluent at mereodnogo inhibitor of general formula 1 according to Claim. 1 or a pharmaceutically acceptable salt and / or hydrate thereof in a therapeutically effective kolichestve.5. Method for the prophylaxis and treatment of hepatitis B virus, comprising administering to the patient an inhibitor of HCV replication in the general formula of claim 1. 1, its pharmaceutically acceptable salt and / or hydrate thereof or a pharmaceutical composition according to claim. 3,1. Ингибиторы репликации вируса гепатита В, представляющие собой бис-ариламиды 9-оксо-9Н-флуорен-2,7-дисульфокислоты общей формулы 1, их фармацевтически приемлемые со
