A personal microclimate control system for sensing cutaneous conditions on a body. The sensors are located on spatially distinct physical locations on a body, adjacent to the cutaneous layer. A controller and connected memory stores the addresses for the sensors. The controller operates the sensors based on their addresses for the purpose of improving thermal comfort. In an embodiment, the controller controls the sensors by executing multiple-input multiple output algorithms. Embodiments are further directed to controlling a plurality of individual electronic effectors as well as to improving system safety, usability and management capabilities.
