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NOUVEL AGONISTE DE LA GHRELINE A ACTION CENTRALE ET UTILISATIONS MEDICALES ASSOCIEES
专利权人:
HELSINN HEALTHCARE SA
发明人:
GIULIANO, CLAUDIO,PIETRA, CLAUDIO,GARCIA RUBIO, SILVINA,GUAINAZZI, ANGELO,MARTINEZ-LOI, MARIELLE
申请号:
CA3089440
公开号:
CA3089440A1
申请日:
2019.03.14
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The new compound 3-(1-(2,3-dichloro-4-methoxyphenyl) ethyl)-1 -methyl-1 -(1,3, 3- trimethylpiperidin -4-yl)urea monohydrochloride salt has a high capability to permeate through the blood-brain barrier and to display, at central nervous system level, a consistent ghrelin agonist activity; the compound is effective in the treatment and/or prevention of a medical condition mediated by the ghrelin receptor in the central nervous system. In particular, in experimental tests, the compound has shown high efficacy in the treatment of neurotoxic damage, with a useful combined pattern of neuroprotective effects both at central and peripheral level. The compound is further useful in the treatment of conditions which require a reduction of the heart rate. The compound is pharmacologically active at low to moderate doses, thus showing a favourable therapeutic index.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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