THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人:
Belen RUBIO-RUIZ,Thomas L BRAY,Ana M PEREZ-LOPEZ,Catherine ADAM,Asier UNCITI-BROCETA
申请号：
US16302671
公开号：
US20200289554A1
申请日:
2017.05.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A method of preparing an active agent or a salt thereof from a pro-drug first compound (1) comprising a propargyl group connected to an oxygen that is directly or indirectly connected to the active agent is provided, wherein the bond between the propargyl group and the oxygen is cleaved by reacting the first compound with palladium or gold, thereby releasing the active agent. Prodrug compositions suitable for use in the method are also provided.
