GRAUERT, Matthias,LINZ, Guenter,SCHMID, Rolf,SIEGER, Peter
申请号：
AU2012256410
公开号：
AU2012256410B2
申请日:
2012.11.26
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2012256410B220160428.pdf#####C:\NRPortbl\DCC\SXD\4760599_ .DOC-2I/1/2012 ABSTRACT The present invention relates to a specific salt of dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1 -piperazinyl] 5 cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1 -methylethyl)-6-oxo-2pteridinyl]amino]-3-methoxy-benzamide, to its crystallisation in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.
