ХИКИ Магали Б. (US),ПЕРРИ Джейсон М. (US),ДИВЕР Дэниел Р. (US),РЕМЕНАР Джулиус Ф. (US),ВЭНДИВЕР Дженнифер (US)
申请号：
RU2013146542/15
公开号：
RU2013146542A
申请日:
2012.03.19
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A pharmaceutical composition comprising (a) a water-insoluble antipsychotic agent； (b) esters of sorbitol and carboxylic acid, where the carboxylic acid contains 4-20 carbon atoms； (c) a polyoxyethylene derivative of esters of sorbitol and carboxylic acid, where the carboxylic acid contains 8 -14 carbon atoms； and (d) an aqueous filler； where the composition forms an aqueous, flocculated, injectable suspension. The pharmaceutical composition according to claim 1, wherein the water-insoluble antipsychotic is aripiprazole, a compound of formula 1 or a compound of formula II, or pharmaceutically acceptable salts thereof, hydrates or solvates of which R is absent and R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R； or R is absent and R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R； R is —CHOC (O) R, —CHOC (O) OR, —CHOC (O) N (R) or —C (O) R； where each R is independently selected from the group consisting of hydrogen, substituted or unsubstituted aliphatic groups and substituted or ezameschennogo aryl； where each R is selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl； wherein is a pharmaceutically acceptable counterion； it is a single or double bond. 3. The pharmaceutical composition according to any one of the above items, wherein the water-insoluble antipsychotic agent is compound A-4 or compound A-74. The pharmaceutical composition according to claim 1, wherein the water-insoluble antipsychotic is olanzapine, a compound of formula III or a compound of formula IV, or pharmaceutically acceptable salts thereof, hydrates or solvates of which are R1. Фармацевтическая композиция, содержащая(а) водонерастворимое антипсихотическое средство；(b) сложные эфиры сорбита и карбоновой кислоты, где карбоновая кислота содержит 4-20 атомов углерода；(с) полиоксиэтиленовое производное сложных эфиров сорбита и карбоновой кислоты, где карбоновая кислота содержит 8-14 атомов углерода； и(d) водный н
