Wendy J. Fantl,David B. Rosen,Alessandra Cesano,Santosh K. Putta,James R. Hackett,Michael Walker,Jing Shi
申请号：
US14572317
公开号：
US20150276745A1
申请日:
2014.12.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.
