Disclosed are methods and systems for adaptive processing of ambulatory electrocardiogram signals. In one embodiment, the method comprises acquiring a plurality of electrocardiogram (ECG) signals and transforming the ECG signals to a component space, thereby producing a set of components representing the ECG signals in the component space. The method further includes evaluating the set of components, adaptively selecting from the set of components a subset of components, and processing the subset of components to identify at least one property of the ECG signals. In some embodiments, the method further includes acquiring non-ECG signals, and adaptively selecting the subset of components comprises adaptively selecting the subset of components based on at least the non-ECG signals.
