Max Delbrck Centrum fr Molekulare Medizin (MDC) Be
发明人:
BLANKENSTEIN, Thomas,WILLIMSKY, Gerald
申请号：
HK16102860.5
公开号：
HK1214942A
申请日:
2016.03.11
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to a method for the production of novel T-cell receptors (TCR) which provide a reduced risk of adverse events in immune therapy, specifically in adoptive T cell transfer. The TCRs produced according to the method of the invention are specific for tumor cells and do not react with healthy tissue. Furthermore provided are nucleic acids encoding the TCR of the invention, vectors and host cells comprising the TCRs of the invention as well as their use is the treatment of tumorous diseases.
