The large annular induction chemical compound which inhibits the protein kinase enzyme, including these chemical compounds, with the medicine constituent, and manner becomes in order which to synthesize these chemical compounds it discloses. This chemical compound does not adjust, the cancer and the dry Ichthyosis, virus Characteristic or bacterial infection, inflammation Characteristic or the autoimmunity Characteristic disease etc, and/or it possesses the application in remedying of the vegetating disease which originates in the kinase activity which is disturbed.タンパク質キナーゼ酵素を阻害する大環状誘導化合物を、これらの化合物を含んでなる医薬組成物、及びこれらの化合物を合成するための方法と共に開示する。かかる化合物は、癌、乾癬、ウイルス性及び細菌性感染、炎症性及び自己免疫性疾患等の調節されない、及び/又は撹乱されたキナーゼ活性に起因する増殖性疾患の治療における用途を有する。
