Compositions and methods for inhibiting expression of transthyretin

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专利权人:

ALNYLAM PHARMACEUTICALS INC.

发明人:

SAH DINAH WEN-YEE,HINKLE GREGORY,ALVAREZ RENE,MILSTEIN STUART,CHEN QINQMIN

申请号：

NZ60240409

公开号：

NZ602404A

申请日:

2009.10.20

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

602404 Discloses a composition comprising a lipid formulation and a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of transthyretin (TTR), wherein the dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising the sequence AUGGAAUACUCUUGGUUAC and the sense strand comprising the sequence GUAACCAAGAGUAUUCCAU, wherein the dsRNA strand is between 19-24 nucleotides in lenth.

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中国工程科技知识中心

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