MedImmune, LLC;Board of Regents, The University of Texas System
发明人:
William Dall'Acqua,Leslie S. Johnson,Elizabeth Sally Ward Ober,William DallAcqua
申请号：
US13898042
公开号：
US08795661B2
申请日:
2013.05.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
