Yong Ji Chung,Eun Mi Kim,Eung Ji Lee,Kyoung Mi Cho
申请号：
US15307587
公开号：
US10093698B2
申请日:
2014.11.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2 shows a melanogenesis increment activity and an adipogenesis inhibitory activity. The peptide, by increasing phosphorylation of MITF, which is a transcription factor for increasing a tyrosinase expression, and CREB for increasing an MITF expression, consequently increases a tyrosinase expression and ultimately increases melanin synthesis. The peptide, by reducing the amount of fat accumulated inside a cell and reducing expressions of perilipin and PPARγ, which contribute to adipogenic mechanism, ultimately inhibits adipogenesis. A composition for remedying or treating melanin hypopigmentation, a composition comprising the peptide, and a pharmaceutical composition for treating or preventing obesity, are provided.
