A device is disclosed for sterilizing objects, such as objects used during medical and dental procedures. A high velocity dry hot air sterilization device integrating a closed, sealed air handling system with a closed, sealed sterilization chamber is described. The sterilization device includes a chamber which carries a sealed instrument container. The sterilization device includes an air handling system for heating and adding velocity to the air which is delivered to the instrument container. The instrument container is configured to allow rapidly flowing hot air to enter from and exhaust to the closed air handling system within the high velocity dry hot air sterilization device without any infiltration of external air to the instrument container or to the high velocity dry hot air sterilizers closed air handling system during the sterilization cycle, thereby preventing infiltration of microbial contaminants to the sterilization device or instrument container during or after sterilization.