Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy

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专利权人:

CITY OF HOPE

发明人:

Diamond Don J.,Manuel Edwin

申请号：

US201615276645

公开号：

US10100314(B2)

申请日:

2016.09.26

申请国别(地区):

美国

年份:

2018

代理人:

Perkinscoie Coie LLP `Dueppen Lara`Tang Yang

摘要：

In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a Salmonella strain comprising a plasmid that expresses an shRNA molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth. In some aspects, the Salmonella strain is an attenuated Salmonella typhimurium strain. In other aspects, the immunosuppressive target is STAT3, IDO1, IDO2, Arginase 1, iNOS, CTLA-4, TGF-β, IL-10, pGE2 or VEGF. In one embodiment, the immunosuppressive target is IDO1 or Arg1 and the shRNA molecule is any one of SEQ ID NO:5-14.

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