The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes comprise mixing a cyclodextrin with an alkylating agent to form a reaction milieu comprising an alkylated cyclodextrin, one or more unwanted components, and one or more drug-degrading impurities； conducting one or more separations to remove the one or more unwanted components from the reaction milieu to form a partially purified solution comprising the alkylated cyclodextrin and the one or more drug-degrading impurities, wherein the one or more separations are ultrafiltration, diafiltration, centrifugation, extraction, solvent precipitation, or dialysis； preparing a phosphate-free activated carbon having a residual conductivity of 10 µS or less by a process comprising subjecting activated carbon to a first carbon washing process comprising adding water, soaking the carbon in the water, and draining the water； and treating the partially purified solution with the phosphate-free activated carbon having a residual conductivity of 10 µS or less and producing the alkylated cyclodextrin； wherein the alkylated cyclodextrin composition has an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the composition per mL of solution in a cell having a 1 cm path length. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.
