The invention is directed to a pharmaceutical composition containing at least one FGF-21 (fibroblast growth factor 21) compound, at least one GLP-1R (glucagon-like peptide-1 receptor) agonist and optionally at least one anti-diabetic drug and/or at least one DPP-4 (dipeptidyl peptidase-4) inhibitor for the treatment of at least one metabolic syndrome and/or atherosclerosis, in particular diabetes, dyslipidemia, obesity and/or adipositas.本發明係關於一種含有至少一種FGF-21(纖維母細胞生長因子21)化合物、至少一GLP-1R(類升糖素肽-1受體)激動劑以及選擇性地至少一抗糖尿病藥物和/或至少一DPP-4(二肽基肽酶-4)抑制劑的醫藥組成物供用於治療至少一代謝症候群和/或動脈粥樣硬化,特別是糖尿病、異常血脂症、肥胖和/或脂肪過多。