#$%^&*AU2019202336A120200116.pdf#####ABSTRACT The invention relates to immunomodulatory compositions comprising one or more extracts from medicinal fungi, and the use of such compositions in the treatment or prevention of conditions or diseases associated with immunological dysfunction, and/or to provide one or more health benefits to an animal subject. In certain embodiments, the invention relates to compositions comprising multiple extracts from a number of medicinal mushrooms, and the use of such compositions to provide one or more health benefits to a subject in need thereof.