Gunnar M. Olsen;Tino Dyhring;Jeppe Kejser Christensen;Jens Damsgaard Mikkelsen;Elsebet Ostergaard Nielsen;John Paul Redrobe;Dan Peters;Daniel B. Timmermann
发明人:
Dan Peters,Daniel B. Timmermann,Elsebet Ostergaard Nielsen,Gunnar M. Olsen,Tino Dyhring,Jeppe Kejser Christensen,John Paul Redrobe,Jens Damsgaard Mikkelsen
申请号：
US12742627
公开号：
US08343960B2
申请日:
2008.11.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
