Hall, Diana,Jimenez, Maria,Poussin, Carine,Thorens, Bernard
申请号：
AU2010302255
公开号：
AU2010302255A1
申请日:
2010.10.01
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention concerns Sipa1l1, a new target involved in adipogenesis modulation. Using a siRNA approach, the inventors demonstrated that decrease in Sipa1l1 activity in preadipocytes and adipose tissue induces a decrease in adipogenesis. Thus, the present invention relates to modulators of Sipa1l1 activity as well as screening test for identification of modulators of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.
