The present disclosure provides a compound of formula (I):or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a growth factor pathway, promoting wound healing, promoting tissue repair, and treating hearing loss, skeletal muscle loss, organ degeneration, tissue damage, neurodegeneration, and muscular atrophy. The disclosure further provides pharmaceutical compositions and combinations. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.本發明提供式(I)化合物:或其醫藥上可接受之鹽,及其用於活化生長因子路徑、促進傷口癒合、促進組織修復及治療聽力損失、骨骼肌損失、器官退化、組織損害、神經退化及肌肉萎縮之治療用途。本揭示內容進一步提供醫藥組合物及組合。本發明亦係關於該等化合物用於研究或其他非治療目的之用途。