Kwang Do Choi,Yong Tack Lee,Myeong Sik Yoon,Hye Suk Hong,Il Hwan Cho,Si Beum Lee,Seong Cheol Bang,Da Won Oh,Min Kyoung Lee
申请号：
US13119538
公开号：
US08637669B2
申请日:
2009.09.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to an improved method of preparing adefovir dipivoxil of Formula 1. The method of the present invention is characterized by using dimethylsulfoxide as a reaction solvent, and comprises a process of preparing adefovir dipivoxil of Formula 1 by allowing adefovir of Formula 2 to react with chloromethylpivalate at a reaction temperature of 30 to 50° C. under the presence of dimethylsulfoxide and triethylamine solvents.
