A dose control mechanism 10 for a syringe includes a plunger 14 having a coarse pitch screw 14B on its exterior surface, a housing 20 having a corresponding coarse pitch guide 20C along the interior surface of the housing 20, a screw 30 having a fine pitch screw 30B which interfaces with a fine pitch nut 18B of an adapter 18, wherein the plunger 14 has an internal annular space 14C within which screw 30 at least partially resides. An accurate dose drug delivery syringe includes such a dose control mechanism 10, a barrel 140, a plumger seal 136, and a barrel adapter assembly 150 having a barrel tip 152 and a needle 154. The syringe may be a fill-at-time-of-use syringe 100, a pre-filled syringe 200, or a safety syringe 300 having integrated needle retraction or needle sheathing safety features, or a combination thereof. Methods of assembly, manufacturing, and operation are similarly disclosed.一種用於注射器之劑量控制機制10，其包含：柱塞14，其外表面具有粗牙螺紋14B；外殼20，沿其內側表面具有相對應粗牙溝20C；螺絲30，具有細牙螺紋30B，該細牙螺紋相接於接合器18之細牙螺帽18B，其中，該柱塞14具有內部環形空間14C，並且，螺絲30的至少一部分係位於該內部環形空間中。精準劑量藥品傳送注射器係包含該劑量控制機制10、針管140、柱塞密封墊136、及具有管尖152及注射針154之針管接合器組件150。該注射器可以為使用時填充式之注射器100、預充式注射器200、或具有整合注射針回縮機制或注射針護套功能之安全性注射器300、或其組合。組裝、製造及操作方法一併於此揭露。
