Rabab Abd El Moneim Khalil El Dib,Shaza Mohamed Adel Al-Massarani,Manal Ahmed Gasmelseed Awad,Ali Ali Hasan El Gamal
申请号：
US16202046
公开号：
US10442833B1
申请日:
2018.11.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
